Advertisements for antidepressant medications might have you believe that simply popping a pill can treat clinical depression. While it\u2019s true that many forms of depression respond well to a combination of medication and therapy, treatment is more complicated for some people.\nThose with treatment-resistant depression can still find themselves struggling with symptoms despite these standard approaches.\nAlso known as treatment-refractory depression, this challenging condition is usually defined as clinical depression that doesn\u2019t respond to at least two different antidepressants. (Some experts define it as depression that doesn\u2019t respond to at least four different antidepressant medications.)\nYour symptoms may range from mild to severe, but the key is that typical treatments haven\u2019t worked for you. Estimates vary, but about one-third of people with depression don\u2019t achieve relief from multiple different antidepressants.\nIf you\u2019ve been diagnosed with treatment-resistant depression, don\u2019t despair: There are several options that may help, including the following.\n\nFirst, confirm your diagnosis. Some people who have been told they have treatment-resistant depression actually have another condition, such as bipolar disorder, or have other health issues that can trigger depression, like hypothyroidism, an eating disorder, or addiction.\nCheck your meds. Before assuming that a medication isn\u2019t working, make sure you\u2019re taking it properly. Some drugs can take up to 12 weeks to be fully effective, so give it time and speak with your clinician to make sure you\u2019re on an adequate dose. Your doctor may also want to try different medications or different classes of medications, or even add another drug to your regimen.\nConsider other types of therapy. There are several different forms of psychotherapy, and you may respond better to one than to another. If one type of counseling hasn\u2019t helped, talk with your therapist and physician about another approach.\n\nExplore Your Treatment Options for Depression\nSometimes even the tips above won\u2019t help alleviate treatment-resistant depression. In that case, your physician may discuss one of the following options with you.\n\nElectroconvulsive therapy (ECT). In this procedure, you are given general anesthesia and electric currents (delivered through paddles) are passed through your brain, intentionally triggering a brief seizure. ECT appears to cause changes in brain chemistry through yet unknown ways that can quickly reverse symptoms of certain mental illnesses, like severe depression. It often works when other treatments are unsuccessful and is approved by the Federal Drug Administration (FDA) for treatment-resistant depression. ECT is typically administered two to three times a week for about 10 to 15 treatments, depending on your response and tolerance.\nTranscranial magnetic stimulation (TMS). This is a noninvasive, FDA-approved treatment for depression that uses a magnet placed close to the left front area of your head. This is performed while you are awake and sitting in a comfortable dentist-like chair. Generally, the treatment is well tolerated, but it is not as effective as ECT for many patients. TMS is performed five days a week for four to six weeks.\n\nFind more information on electroconvulsive therapy. To make an appointment, call 412-245-5063.