The Centers for Disease Control and Prevention (CDC) reports that 91 Americans die every day from an opioid overdose.\nThe number of people hooked on opioids, such as morphine, heroin, and codeine, has increased dramatically in the past decade. Doctors and researchers are looking at ways to address substance abuse and help people safely withdraw from these drugs.\u00a0Medication-assisted therapy\u00a0is one tool in the arsenal.\nThese treatment methods commonly include the use of buprenorphine and long-acting naltrexone.\nBoth can be prescribed by a health care provider and are recommended as part of a comprehensive substance abuse program that includes counseling and behavioral therapy. Each works differently to help you deal with addiction.\nWhat\u2019s the Difference Between Buprenorphine and Naltrexone?\nHow\u00a0Buprenorphine\u00a0Works\nBuprenorphine\u00a0produces similar feelings of a high on opiates but at a much weaker level. This helps people avoid withdrawal symptoms and manage cravings so they can safely lower their dependency on the drugs. Because buprenorphine still delivers a small high, it does have the potential for abuse. However, it is much less likely that someone will overdose.\nIt is often prescribed by a doctor as a\u00a0sublingual tablet, meaning you put it under your tongue and let it dissolve. The tablet also contains naloxone, a medication that blocks the effects of opioids and helps reduce dependency. Naloxone is what first responders administer when someone has overdosed.\nHow Naltrexone\u00a0Works\nNaltrexone\u00a0is an extended-release injection medication. It is given once a month and blocks the high from opioids. This is intended to reduce cravings for the drug. Naltrexone can cause serious side effects if you take opioids while using it. People need to be clean from opioids for at least seven to 10 days before starting this therapy.\nUnlike buprenorphine, naltrexone doesn\u2019t carry a risk of misuse or overdose. However, relapse can be riskier after therapy when naltrexone ends. The medication may make you less tolerant to the same doses of drugs you were taking before trying to quit.\nBoth medications carry similar gastrointestinal side effects, nervousness, and difficulty sleeping.\nFinding a Drug Treatment Program\nAny attempts to withdraw from prescription or illegal drugs should be done under the supervision of a medical professional. Medication-assisted therapy with buprenorphine or long-acting naltrexone has been proven an effective part of a treatment program that includes psychological counseling.