Neurosurgery and Brain Health What Is a Glioblastoma? By Neurosurgery, August 25, 2017 The most common type of brain tumor, glioblastoma, is also the most aggressive — and hardest to treat. Glioblastoma is a fast-growing cancer that forms tumors on the supportive tissue of the brain. This disease most often affects adults and develops in the brain’s frontal and temporal lobes. Learn more about glioblastoma on the UPMC Department of Neurosurgery website. Fill out the form to contact the UPMC Neurosurgery team. Highly malignant because its cells rapidly reproduce, glioblastoma tumors are remarkably difficult to remove, though some patients can undergo surgery. Doctors do not know the exact cause of glioblastoma. Glioblastoma Symptoms The symptoms of glioblastoma can vary based on the location of the tumor. Some warning signs include: Headaches Confusion Seizures Nausea or vomiting Weakness or loss of sensation in the arms and/or legs Speech, vision, or memory problems Personality changes How Glioblastoma Is Treated Glioblastoma tumors contain a variety of cells, making them particularly difficult to treat. As a result, people diagnosed with glioblastoma may have to undergo a combination of treatments, including radiation, chemotherapy, and surgery. Doctors can identify glioblastomas using imaging studies, including MRIs and CT scans.