U.S. health officials have authorized bivalent boosters for the Moderna and Pfizer-BioNTech COVID-19 vaccines.
- On Aug. 31, 2022, the U.S. Food and Drug Administration (FDA) authorized the Moderna booster for people 18 and older and the Pfizer booster for people 12 and older. On Sept. 1, 2022, the Centers for Disease Control and Prevention (CDC) officially recommended the new boosters.
- On Oct. 12, 2022, the FDA authorized the bivalent Moderna booster for children 6 and older and the bivalent Pfizer booster for children 5 and older. The CDC followed by recommending the booster for the younger age groups.
- Finally, on Dec. 8, 2022, the FDA authorized the bivalent Pfizer and Moderna boosters for children 6 months old and up. The CDC also recommended the booster for children 6 months and older.
The previously authorized monovalent boosters are no longer authorized for people 6 months and older.
Here’s what to know about the new boosters and when and where you can receive them.
Please note: Scheduling an appointment for a bivalent booster for children aged 6 months to 5 years at a UPMC location may not be available at this time. Please check back.
What Is the Bivalent Booster?
The new boosters are “bivalent” because they target the BA.4 and BA.5 subvariants of the Omicron variant as well as the original strain of SARS-CoV-2, the coronavirus that causes COVID-19.
The original COVID-19 boosters protected against the original strain of the coronavirus. The bivalent booster protects against the original virus as well as the Omicron BA.4 and BA.5 subvariants.
The BA.4 and BA.5 subvariants first emerged in late 2021 and spread quickly. They became the dominant form of the coronavirus in the United States in the summer of 2022. The subvariants are more transmissible and could more easily evade antibodies from previous vaccines and boosters.
The bivalent booster targets the “spike” protein for both the original strain of the coronavirus as well as BA.4 and BA.5. The goal is to create antibodies specifically against BA.4 and BA.5, providing stronger protection against the subvariants. This protection will likely also offer protection against new/emerging variants similar to or deriving from BA.4 and BA.5.
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Who Is Eligible for the Bivalent Booster?
Americans age 6 months and older are eligible for the bivalent booster. The original monovalent COVID-19 booster is no longer authorized.
You can get the bivalent booster even if you have received one or more doses of the original COVID-19 vaccine.
Children 6 months old through 4 years old who have not completed the three-dose primary series of the Pfizer vaccine now will get the bivalent vaccine as the third dose of their primary series after two monovalent doses. Children 6 months through 4 years old who completed the three-dose primary series of the Pfizer vaccine are not yet eligible for the bivalent booster.
When Can I Get the Bivalent Booster?
In most cases, you can receive the bivalent booster two months or more after your previous vaccine dose.
For people receiving their initial doses of the COVID-19 vaccine, that means you can get the bivalent booster two months or more after the final dose of your primary vaccine series. For people who have received boosters, you can get the bivalent booster two months or more after your most recent booster.
People who are moderately or severely immunocompromised also can get the bivalent booster at least two months after their previous vaccine dose.
If you recently had COVID-19 and are vaccinated, you can get the bivalent booster when you are well — as long as two months have passed from your previous vaccine dose.
Children 6 months through 4 years old who have completed the three-dose primary series of the Pfizer vaccine aren’t yet eligible for the bivalent booster.
Talk to your doctor if you’re unsure about whether you or your loved ones can get the bivalent booster. You also can use the CDC’s online tool to determine if you’re eligible.
Which Bivalent Booster Can I Get?
Unless you are between the ages of 6 months and 5 years old, the bivalent booster you get does not have to be from the same manufacturer as your primary vaccine or booster.
If you are age 5 and older, you can receive either the Pfizer or Moderna bivalent. It doesn’t matter which manufacturer you received for your previous vaccine and booster doses.
Where Can I Get the Bivalent Booster?
Individuals who meet the criteria can schedule a COVID-19 bivalent booster by calling their primary care office. If you are not an adult, you can ask someone to contact a provider. Ask if they offer the COVID-19 bivalent booster.
Scheduling an appointment for a bivalent booster for children aged 6 months to 5 years at a UPMC location may not be available at this time. Please check back.
Is the Bivalent Booster Safe?
The bivalent booster is safe and has a safety profile similar to other doses of vaccine.
The most commonly reported side effects after a booster dose of the COVID-19 vaccine in clinical trial participants were pain, redness, and swelling at the injection site. It also can cause short-term, flu-like symptoms like:
- Muscle pain.
- Joint pain.
- Swollen lymph nodes under the arm where you got the injection.
These symptoms are often minor and go away within a couple of days. The booster went through extensive safety evaluation during clinical trials.
UPMC recommends COVID-19 vaccination and boosters for everyone aged 6 months and older. Data consistently show the vaccine reduces the risks of serious complications of COVID-19, including hospitalization and death.
Editor's Note: This article was originally published on , and was last reviewed on .
Dani Blum, New York Times, What to Know About the New Booster Shots. Link
Centers for Disease Control and Prevention, CDC Recommends the First Updated COVID-19 Booster. Link
Food and Drug Administration, Coronavirus (COVID-19) Update: FDA Authorizes Moderna, Pfizer-BioNTech Bivalent COVID-19 Vaccines for Use as a Booster Dose. Link
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