Neurosurgery and Brain Health How Brain Chemicals Influence Mood and Health By Neurosurgery, September 4, 2016 The brain communicates with itself by transmitting chemicals from one neuron, or nerve, to the other. And this regular, rapid-fire messaging plays a big role in how you feel and function each day. These neurotransmitter chemicals are classified into two basic categories: excitatory, meaning they stimulate brain activity, or inhibitory, meaning they have a more calming effect. Learn more about a few common brain chemicals and how they impact your thinking and mood. Find out how different brain chemicals impact your thinking and mood in a variety of ways. Click To Tweet Four Important Brain Chemicals Serotonin You probably already know that serotonin plays a role in sleep and in depression, but this inhibitory chemical also plays a major role in many of your body’s essential functions, including appetite, arousal, and mood. Many antidepressants target serotonin receptors to improve your mood and lessen depressive symptoms. Interestingly, most of your serotonin is stored in the intestine, and this chemical may play a role in digestive functioning as well. Dopamine Dopamine controls many functions, including behavior, emotion, and cognition. This chemical also communicates with the front part of your brain, which is associated with pleasure and reward. On the positive side, it helps motivate you to work toward achieving a reward. However, many illegal drugs also target dopamine receptors, contributing to drug and alcohol addiction. Because dopamine is related to movement, low levels have also been linked to Parkinson’s disease. Glutamate This is the most common excitatory neurotransmitter, found throughout your brain and spinal cord. Glutamate has many essential functions, including early brain development, cognition, learning, and memory. Norepinephrine This chemical, also called noradrenaline, can sometimes act as a hormone as well. Its primary role is part of your body’s stress response. It works with the hormone adrenaline to create the “fight-or-flight” feeling. Norephinephrine may also be used as a drug to raise or maintain blood pressure in certain illnesses. Chemicals, Hormones, and the Brain Some of these neurotransmitters, such as norepinephrine, are also hormones or have some effect in releasing hormones in the body. Adrenaline, cortisol, melatonin, and other hormones can affect your mood or even influence the health of your brain. Cortisol is a hormone released when you’re stressed. It’s helpful at times, but too much of it for too long can cause memory loss as you age. Imbalances in neurotransmitters are present in many conditions, including schizophrenia, depression, bipolar disorder, autism, and Parkinson’s disease. Some medications target these receptors to allow your body to receive more or less of certain chemicals, while some drugs act similar to these chemicals to invoke similar responses in your body. Maintaining a balance in these brain chemicals and hormones is key to feeling a balanced mood. You can help maintain this health to some extent through a balanced diet, limited stress, and exercise.