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According to the Centers for Disease Control and Prevention (CDC), deaths in the United States from prescription opioids, such as oxycodone, hydrocodone, and methadone, have quintupled since 1999. From 1999 to 2016 there were over 200,000 deaths from drug overdoses.

Opioids are frequently prescribed to relieve pain. Opioid drugs are chemically related and interact with opioid receptors on nerve cells in the body and the brain. In addition to relieving pain, opioids can cause euphoria, which may lead to misuse and overdose.

Learn more about addiction treatment services available at UPMC. 

Over time, opioid use can lead to tolerance, which is the need for more of a substance to achieve the desired effect (or a reduced effect when taking the same amount of the substance).

It’s important to recognize the signs and symptoms of opioid use disorder. If you notice any of these symptoms in family or friends, help is available.

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Opioid Abuse and Dependence

Opioid pain relievers are generally safe when taken for a short period of time (generally up to a few weeks) and as prescribed. Regular or prolonged use, even as prescribed, can cause dependence.

The National Institute of Drug Abuse (NIDA) defines addiction as a chronic, relapsing brain disease that is characterized by compulsive drug seeking and use, despite harmful consequences.

Opioid Misuse or Risky Use Symptoms

  • Taking the substance/medication in larger amounts or longer than intended
  • Taking someone else’s medication, even for a legitimate purpose such as to relieve pain
  • An inability to cut down or control the use of the substance/medication
  • Craving or a strong desire to use the substance/medication
  • Recurrent use of the substance/medication despite harmful consequences
  • Using in contradiction to prescribing guidelines (e.g., combining the substance/medication with alcohol or other drugs)
  • Using the substance in a manner other than intended (e.g., crushing pills)

Social Indications of Opioid Use Disorder

Often, people who are struggling with opioid use disorder will start behaving differently. Here are some indications to look for:

  • Withdrawal from social and recreational activities
  • Changes in behavior or mood
  • Financial problems
  • Making bad or reckless decisions
  • Avoiding friends and family
  • Missing school or work due to use
  • Suspension from school or job loss due to a drug-related incident

Opioid Overdose Symptoms

  • Poor coordination
  • Shallow breathing or breathing stops
  • Person unresponsive
  • Drowsiness
  • Pale, clammy skin
  • Lips and fingernails turn blue or gray
  • Nausea, vomiting
  • Slurred speech

If you suspect an overdose, call 911, administer naloxone (Narcan if available, and do not leave the person alone until help arrives.

Treatment is available for opiate use disorders — and treatment works! If you aren’t sure what to do, seek advice from the experts at UPMC Addiction Medicine Program — you could save a life.

About Behavioral Health

UPMC Western Psychiatric Hospital provides high-quality, cutting-edge psychiatric and addiction services. We serve all ages of people at all stages of recovery. We provide diagnostic services and treatment for all types of psychiatric and mental health conditions. We serve more than 25,000 patients each year. Our hospital, in Pittsburgh’s Oakland neighborhood, has more than 400 inpatient beds. Western Psychiatric partners academically with the Department of Psychology at the University of Pittsburgh’s School of Medicine. Together they conduct research and clinical trials.